MICROBIAL SYNTHESIS OF A GLYCOSIDASE INHIBITOR

Autores/as

  • Dmitry Kulev Russian Academy of Agricultural Sciences (VNIIPAKK RAAS)
  • Natalia Sharova All-Russia Scientific Research Institute for Food Additives (VNIIPD)

Palabras clave:

glycosidase inhibitor diabetes, functional foods

Resumen

Effect of inhibitors synthesized by the strains of Streptomyces violaceus VKM  Ac-1734 and Streptomyces lucensis VKM ?c-1743 on amylases of divers origin was studied. It was found that the inhibitors have a different influence over fungal, pancreatic and human blood amylases. It is established that the inhibitors under study are substances of a pseudo-oligosaccharide nature and are active and stable over a wide pH and temperature range. Physicochemical and biochemical properties of the isolated inhibitors were compared with the known microbial ?-glucosidases inhibitors. A hypoglycemic effect was established in laboratory rats.

Biografía del autor/a

Dmitry Kulev, Russian Academy of Agricultural Sciences (VNIIPAKK RAAS)

Profesor, Doctor of Engineering, Academician of the Academy of Encyclopedic Sciences,  Research and Development Director  at the All’Russia Research Institute for Food Flavours, Acids and Colours of the Russian Academy of Agricultural sciences (VNIIPAKK RAAS).Author of more than 400 research papers on the above topics, including several monographs, articles, patents and discoveries. Scientific adviser for students and postgraduates

Natalia Sharova, All-Russia Scientific Research Institute for Food Additives (VNIIPD)

Doctor of Engineering. Graduated from the State Saint-Petersburg Technological University in 1990.Laboratory chief for the citric acid production biotechnology at the All-Russia Research Institute for Food Additives, Sain-Petersburg, Russia (www.vniipakk.uspb.ru)Author of 196 research papers, including 13 patents, 2 monographs, more than 50 articles in journals, 44 of them in peer-reviewed journals and translated publications.

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Publicado

2015-08-20

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